United States securities and exchange commission logo October 12, 2021 Rick Pauls President and Chief Executive Officer DiaMedica Therapeutics Inc. Two Carlson Parkway, Suite 260 Minneapolis, Minnesota 55447 Re: DiaMedica Therapeutics Inc. Registration Statement on Form S-3 Filed October 5, 2021 File No. 333-260066 Dear Mr. Pauls: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Michael Davis at 202-551-4385 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Amy Culbert