DiaMedica Therapeutics, Inc.

Pipeline

Intended to Restore Natural, Healthy Function

DiaMedica’s lead candidate, DM199 (rhKLK1), is a recombinant form of the human tissue KLK1 protein which enhances blood flow and vascular health by increasing the available levels of nitric oxide (NO), prostacyclin (PGI2), and endothelium-derived hyperpolarizing factor (EDHF). Through this novel mechanism of action, DM199 has the potential to modify disease progression in preeclampsia and fetal growth restriction and enhance collateral circulation in acute ischemic stroke.

Preeclampsia (PE) and Fetal Growth Restriction (FGR)

10 Million

Global cases of preeclampsia per year 1

>300 Thousand

Annual cases of FGR, PE and related hypertensive pregnancy disorders in the U.S. 2,3

30 Thousand

Cases of early-onset preeclampsia (<34 weeks gestation) per year in the U.S.4,5

~20 Thousand

Cases of early-onset fetal growth restriction (<32 weeks gestation) per year in the U.S.6

1. Preeclampsia Foundation. “Preeclampsia and Maternal Mortality: A Global Burden”. Preeclampsia And Maternal Mortality: A Global Burden
2. Baschat et al. (2021). FIGO initiative on fetal growth: Best practice advice for screening, diagnosis, and management of fetal growth restriction. International Journal of Gynecology & Obstetrics, 152(S1), 3-12.
3. Chappell, L. C., et al. (2021). Pre-eclampsia. The Lancet, 398(10297), 341–354.
4. Teka, H., et al. (2023). Clinical presentation, maternal-fetal, and neonatal outcomes of early-onset versus late onset preeclampsia-eclampsia syndrome in a teaching hospital in a low-resource setting: A retrospective cohort study. PloS one, 18(2), e0281952.
5. E., G., Akurati, et al. (2018). Early onset and late onset preeclampsia-maternal and perinatal outcomes in a rural teritiary health center. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 7(6), 2266–2269.
6. Dall'Asta, A., et al. (2017). Early onset fetal growth restriction. Maternal health, neonatology and perinatology, 3, 2.

 


DM199 for Pregnancy Complications

Acute Ischemic Stroke (AIS)

 

>7.5 Million

Ischemic strokes per year globally

~700 Thousand

Ischemic strokes per year in the U.S.

~80%

Of AIS patients have no direct treatment options

World Stroke Organization Global Fact Sheet 2022 & CDC Stroke Facts October 2022


DM199 for Acute Ischemic Stroke

The safety and effectiveness of DM199 for the treatment of acute ischemic stroke or preeclampsia has not been established and is limited to investigational use only.